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PER2 /Period circadian clock 2 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.
Gene Name: | period circadian clock 2 |
Synonyms: | PER2, HPER2, Period homolog 2 (Drosophila), Period 2, KIAA0347, Period (Drosophila) homolog 2, Period circadian clock 2, Period circadian protein 2, FASPS |
Target Sequences: | NM_022817 NP_073728.1 O15055 |
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