PDX1

pancreatic and duodenal homeobox 1

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

PDX1 (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST (1)

His, N-Terminal (1)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human PDX1 Protein (Recombinant 6His, N-terminus) (Tyr8-Arg277) - LS-G26476

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

33 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human PDX1 Protein (Recombinant GST) (Full Length) - LS-G29075

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

58.08 kDa

Price:

2 µg/$439

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Mouse PDX1 Protein (Recombinant His-GST) (aa1-284) - LS-G25925

Source:

E. coli

Tag:

His-GST

Molecular Weight:

61.0 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$3,201

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Human PDX1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66029

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.6 kDa

Price:

20 µg/$1,107

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PDX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98959

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.6 kDa

Price:

100 µg/$494

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Human PDX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76778

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.6 kDa

Price:

20 µg/$150

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Human PDX1 Protein (Recombinant His, N-Terminal) - LS-G144347

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

30.6 kDa

Price:

50 µg/$419

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