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PDPN / Podoplanin

podoplanin

May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

Gene Name:	podoplanin
Synonyms:	PDPN, AGGRUS, HT1alpha-1, Glycoprotein 36, Glycoprotein, 36-KD, gp36, gp38, OTS8, PA2.26, PA2.26 antigen, Podoplanin, T1A, gp40, HT1A-1, HT1alpha-2, p38, T1-alpha, T1A-2
Target Sequences:	NM_006474 NP_006465.3 Q86YL7

Publications (14)

Characterization of an antigenic determinant preferentially expressed by type I epithelial cells in the murine thymus. Farr A, Nelson A, Hosier S. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1992 40:651-64. [PubMed:1374092]

Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. Farr AG, Berry ML, Kim A, Nelson AJ, Welch MP, Aruffo A. The Journal of experimental medicine. 1992 176:1477-82. [PubMed:1402691] [PMC:PMC2119410]

T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. Schacht V, Ramirez MI, Hong YK, Hirakawa S, Feng D, Harvey N, Williams M, Dvorak AM, Dvorak HF, Oliver G, Detmar M. The EMBO journal. 2003 22:3546-56. [PubMed:12853470] [PMC:PMC165612]

Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. Katakai T, Hara T, Sugai M, Gonda H, Shimizu A. The Journal of experimental medicine. 2004 200:783-95. [PubMed:15381731] [PMC:PMC2211971]

Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis. Crnic I, Strittmatter K, Cavallaro U, Kopfstein L, Jussila L, Alitalo K, Christofori G. Cancer research. 2004 64:8630-8. [PubMed:15574770]

Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Schacht V, Dadras SS, Johnson LA, Jackson DG, Hong YK, Detmar M. The American journal of pathology. 2005 166:913-21. [PubMed:15743802] [PMC:PMC1602360]

A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion. Hara T, Katakai T, Lee JH, Nambu Y, Nakajima-Nagata N, Gonda H, Sugai M, Shimizu A. International immunology. 2006 18:301-11. [PubMed:16410312]

Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system. Gittenberger-de Groot AC, Mahtab EA, Hahurij ND, Wisse LJ, Deruiter MC, Wijffels MC, Poelmann RE. Anatomical record (Hoboken, N.J. : 2007). 2007 290:115-22. [PubMed:17441204]

The role of lymphoid tissue inducer cells in splenic white pulp development. Withers DR, Kim MY, Bekiaris V, Rossi SW, Jenkinson WE, Gaspal F, McConnell F, Caamano JH, Anderson G, Lane PJ. European journal of immunology. 2007 37:3240-5. [PubMed:17948268]

Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Mahtab EA, Wijffels MC, Van Den Akker NM, Hahurij ND, Lie-Venema H, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC. Developmental dynamics : an official publication of the American Association of Anatomists. 2008 237:847-57. [PubMed:18265012]

Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node. Mahtab EA, Vicente-Steijn R, Hahurij ND, Jongbloed MR, Wisse LJ, DeRuiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-de Groot AC. Developmental dynamics : an official publication of the American Association of Anatomists. 2009 238:183-93. [PubMed:19097191]

Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes. Porter DW, Hubbs AF, Mercer RR, Wu N, Wolfarth MG, Sriram K, Leonard S, Battelli L, Schwegler-Berry D, Friend S, Andrew M, Chen BT, Tsuruoka S, Endo M, Castranova V. Toxicology. 2010 269:136-47. (ICC, IHC; Mouse) [PubMed:19857541]

Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. Kabgani N, Grigoleit T, Schulte K, Sechi A, Sauer-Lehnen S, Tag C, Boor P, Kuppe C, Warsow G, Schordan S, Mostertz J, Chilukoti RK, Homuth G, Endlich N, Tacke F, Weiskirchen R, Fuellen G, Endlich K, Floege J, Smeets B, Moeller MJ. PloS one. 2012 7:e34907. (WB; Mouse) [PubMed:22529955] [PMC:PMC3329559]

Rare SOX2+Airway Progenitor Cells Generate KRT5+Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection. Ray S, Chiba N, Yao C, Guan X, McConnell AM, Brockway B, Que L, McQualter JL, Stripp BR. Stem cell reports. 2016 November;7:817-825. (Mouse) [Full Text Article] [PubMed:27773701] [PMC:PMC5106521] Related Antibodies: LS-C143022.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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