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PDLIM3 contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy.
Gene Name: | PDZ and LIM domain 3 |
Synonyms: | PDLIM3, ALP, Actinin-associated LIM protein, PDZ and LIM domain 3, Enigma homolog, PDZ and LIM domain protein 3 |
Target Sequences: | NM_014476 NP_055291.2 Q53GG5 |
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