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PDLIM2 / SLIM is a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene Name: | PDZ And LIM Domain 2 (mystique) |
Synonyms: | PDLIM2, MYSTIQUE, PDZ-LIM protein mystique, PDZ and LIM domain protein 2, SLIM |
Target Sequences: | NM_021630 NP_067643.3 Q96JY6 |
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