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PDI / P4HB

prolyl 4-hydroxylase, beta polypeptide

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

Gene Name: prolyl 4-hydroxylase, beta polypeptide
Synonyms: P4HB, ERBA2L, DSI, GIT, p4HB, p4Hbeta, PDIA1, PHDB, PO4DB, PROHB, Protocollagen hydroxylase, Protein disulfide-isomerase, PO4HB, PDI
Target Sequences: NM_000918 NP_000909.2 P07237

Publications (4)

1
Proteomic analysis of solid pseudopapillary tumor of the pancreas reveals dysfunction of the endoplasmic reticulum protein processing pathway. Zhu Y, Xu H, Chen H, Xie J, Shi M, Shen B, Deng X, Liu C, Zhan X, Peng C. Molecular & cellular proteomics : MCP. 2014 13:2593-603. (WB; Human, Rat) [Full Text Article] [PubMed:24997997] [PMC:PMC4188989]
2
Temporal gene expression profiling of the rat knee joint capsule during immobilization-induced joint contractures. Wong K, Sun F, Trudel G, Sebastiani P, Laneuville O. BMC musculoskeletal disorders. 2015 16:125. (ICC; Human, Rat) [Full Text Article] [PubMed:26006773] [PMC:PMC4443538] Related Antibodies: LS-B3137.
3
Localization of collagen modifying enzymes on fibroblastic reticular cells and follicular dendritic cells in non-neoplastic and neoplastic lymphoid tissues. Ohe R, Aung NY, Meng H, Kabasawa T, Suto A, Tamazawa N, Yang S, Kato T, Yamakawa M. Leukemia & lymphoma. 2015 57:1687-96. (IHC; Human) [Full Text Article] [PubMed:26700650] [PMC:PMC4926777]
4
Patterns of production of collagen-rich deposits in peripheral nerves in response to injury: A pilot study in a rabbit model. Michael Rivlin, Andrew Miller, Jacob Tulipan, Pedro K Beredjiklian, Mark L Wang, Jolanta Fertala, Andrzej Steplewski, James Kostas, Andrzej Fertala. Brain and behavior. 2017 July;7:e00659. [Full Text Article] [PubMed:28729925] [PMC:PMC5516593] Related Antibodies: LS-C827808.
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ELISA Kits (18)
Custom (4)
Sandwich (12)
Sandwich CLIA (2)
PDI / P4HB (18)
Human (6)
Mouse (3)
Rat (1)
Chicken (2)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (2)
96-Well Strip Plate (15)
No (18)
Cell Culture Supernatants (2)
EDTA Plasma (1)
Heparin Plasma (1)
Plasma (7)
Serum (8)
Tissue Homogenates (5)
PDI / P4HB ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
PDI / P4HB ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
PDI / P4HB ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
PDI / P4HB ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
PDI / P4HB ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
PDI / P4HB ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PDI / P4HB ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PDI / P4HB ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PDI / P4HB ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PDI / P4HB ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PDI / P4HB ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PDI / P4HB ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PDI / P4HB ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PDI / P4HB ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
PDI / P4HB ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
PDI / P4HB ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$968
PDI / P4HB ELISA Kit
Select
Sandwich
Human
93.8 - 6000 pg/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
PDI / P4HB ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).