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PDE6D / PDE6 Delta

phosphodiesterase 6D, cGMP-specific, rod, delta

Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.

Gene Name: phosphodiesterase 6D, cGMP-specific, rod, delta
Family/Subfamily: Phosphodiesterase , PDE - photoreceptor
Synonyms: PDE6D, GMP-PDE delta, PDED, Phosphodiesterase 6d, Phosphodiesterase delta, Protein p17, Pde delta
Target Sequences: NM_002601 NP_002592.1 O43924

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
PDE6D / PDE6 Delta (6)
No (6)
GST (1)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
PDE6D / PDE6 Delta Protein
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E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
PDE6D / PDE6 Delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
17.2 kDa
20 µg/$150
PDE6D / PDE6 Delta Protein - Purified recombinant protein PDE6D was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
17.2 kDa
20 µg/$1,107
PDE6D / PDE6 Delta Protein - 12.5% SDS-PAGE of human PDE6D stained with Coomassie Blue
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Wheat Germ Extract
GST
42.24 kDa
10 µg/$479; 25 µg/$670
PDE6D / PDE6 Delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
17.2 kDa
100 µg/$494
PDE6D / PDE6 Delta Protein
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E. coli
His, N-Terminal
17.2 kDa
50 µg/$419
Viewing 1-6 of 6 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).