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Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
Gene Name: | phosphodiesterase 6D, cGMP-specific, rod, delta |
Family/Subfamily: | Phosphodiesterase , PDE - photoreceptor |
Synonyms: | PDE6D, GMP-PDE delta, PDED, Phosphodiesterase 6d, Phosphodiesterase delta, Protein p17, Pde delta |
Target Sequences: | NM_002601 NP_002592.1 O43924 |
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