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Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Gene Name: | phosphodiesterase 3B, cGMP-inhibited |
Family/Subfamily: | Phosphodiesterase , PDE - cAMP/cGMP dual-specific, cGMP-inhibited |
Synonyms: | PDE3B, CGIPDE1, CGI-PDE B, CGIP1, HcGIP1, Phosphodiesterase 3b, Phosphodiesterase type 3B, RPDE-3B, RcGIP1 |
Target Sequences: | NM_000922 NP_000913.2 Q13370 |
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