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Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).
Gene Name: | phosphodiesterase 1C, calmodulin-dependent 70kDa |
Family/Subfamily: | Phosphodiesterase , PDE - cAMP/cGMP dual-specific, Ca/Calmodulin-dependent |
Synonyms: | PDE1C, HCam-3, Hcam3, Phosphodiesterase 1c, Cam-PDE 1C |
Target Sequences: | NM_005020 NP_005011.1 Q14123 |
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