PDE12

phosphodiesterase 12

Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

PDE12 (4)

Publications

No (4)

Tag

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (2)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

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Human PDE12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86278

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

20 µg/$215

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PDE12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104806

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

100 µg/$710

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Human PDE12 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70100

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.2 kDa

Price:

20 µg/$1,107

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Mouse PDE12 Protein (Recombinant His-T7) (aa290-602) - LS-G25635

Source:

E. coli

Tag:

His-T7

Molecular Weight:

39 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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