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PDE10A belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
Gene Name: | phosphodiesterase 10A |
Family/Subfamily: | Phosphodiesterase , PDE - cAMP/cGMP dual-specific |
Synonyms: | PDE10A, HSPDE10A, Pde 10, PDE10, Phosphodiesterase 10A |
Target Sequences: | NM_006661 NP_006652.1 Q9Y233 |
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