PCSK9

proprotein convertase subtilisin/kexin type 9

Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na+ channel (ENaC)-mediated Na+ absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.

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Products

ELISA Kits (30)

Type

Custom (1)

Sandwich (27)

Sandwich CLIA (2)

Target

PCSK9 (30)

Reactivity

Human (8)

Mouse (7)

Rat (5)

Chicken (1)

Guinea pig (2)

Monkey (2)

Porcine (1)

Rabbit (3)

Sheep (1)

Format

12 x 8-Well Microstrips (3)

96-Well Microplate (7)

96-Well Strip Plate (19)

Publications

No (30)

Sample Type

Cell Culture Supernatants (7)

EDTA Plasma (1)

Heparin Plasma (1)

Plasma (25)

Serum (26)

Tissue Homogenates (9)

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Rat PCSK9 (Sandwich ELISA) ELISA Kit - LS-F9168

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Porcine PCSK9 (Sandwich ELISA) ELISA Kit - LS-F38573

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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Monkey PCSK9 (Sandwich ELISA) ELISA Kit - LS-F50828

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

1.1 - 800 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$1,041

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Monkey PCSK9 (Sandwich ELISA) ELISA Kit - LS-F47169

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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Rat PCSK9 (Sandwich ELISA) ELISA Kit - LS-F22819

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human PCSK9 (Sandwich ELISA) ELISA Kit - LS-F717

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Mouse PCSK9 (Sandwich ELISA) ELISA Kit - LS-F35061

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse PCSK9 (Sandwich ELISA) ELISA Kit - LS-F23851

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Mouse PCSK9 (Sandwich ELISA) ELISA Kit - LS-F2857

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

Select

Rat PCSK9 (Sandwich ELISA) ELISA Kit - LS-F12275

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

Select

Mouse PCSK9 (Sandwich ELISA) ELISA Kit - LS-F24883

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$624

Select

Human PCSK9 (Sandwich ELISA) ELISA Kit - LS-F24647

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$624

Select

Human PCSK9 (Sandwich ELISA) ELISA Kit - LS-F2856

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

Select

Human PCSK9 (Sandwich ELISA) ELISA Kit - LS-F7619

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

Select

Mouse PCSK9 (Sandwich ELISA) ELISA Kit - LS-F8053

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.63 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$748

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Mouse PCSK9 (Custom ELISA) ELISA Kit - LS-F14258

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$585

Select

Mouse PCSK9 (CLIA) ELISA Kit - LS-F30748

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Guinea pig PCSK9 (Sandwich ELISA) ELISA Kit - LS-F35060

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human PCSK9 (Sandwich ELISA) ELISA Kit - LS-F35062

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat PCSK9 (Sandwich ELISA) ELISA Kit - LS-F35063

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human PCSK9 (CLIA) ELISA Kit - LS-F29999

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

125 - 8000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Rabbit PCSK9 (Sandwich ELISA) ELISA Kit - LS-F33721

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human PCSK9 (Sandwich ELISA) ELISA Kit - LS-F50011

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

1.2 - 300 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$610

Select

Rabbit PCSK9 (Sandwich ELISA) ELISA Kit - LS-F55734

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

Select

Rat PCSK9 (Sandwich ELISA) ELISA Kit - LS-F57296

Type:

Sandwich

Reactivity:

Rat

Range:

62.5 - 4000 pg/ml

Sample Types:

Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum

Price:

1 Plate/$699

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