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PCDH11X / Protocadherin 11 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Disruption of this gene may be associated with developmental dyslexia. Alternative splicing results in multiple transcript variants.
Gene Name: | protocadherin 11 X-linked |
Family/Subfamily: | Cadherin , not assigned-Cadherin |
Synonyms: | PCDH11X, KIAA1326, PCDH-X, PCDHX, PCDH22, PCDHY, Protocadherin Y, Protocadherin-S, Protocadherin 11 X-linked, Protocadherin 11X, Protocadherin X, PCDH11, Protocadherin 11, Protocadherin 22, Protocadherin XY, Protocadherin-11, Protocadherin-11 X-linked |
Target Sequences: | NM_014522 NP_055337.1 Q9BZA7 |
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