PBX1

pre-B-cell leukemia homeobox 1

Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PBX1 (5)

Publications

No (5)

Tag

GST, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

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Human PBX1 Protein (Recombinant GST, N-terminus) (aa213-321) - LS-G59515

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

37.7 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PBX1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66636

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.4 kDa

Price:

20 µg/$1,107

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PBX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99802

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.4 kDa

Price:

100 µg/$494

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Human PBX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78151

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.4 kDa

Price:

20 µg/$150

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Human PBX1 Protein (Recombinant GST, N-terminus) (aa311-403) - LS-G135957

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

35.86 kDa

Price:

10 µg/$479; 25 µg/$670

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