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Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.
Gene Name: | parvin, alpha |
Synonyms: | PARVA, Actopaxin, Alpha-parvin, CH-ILKBP, Parvin, alpha, MXRA2 |
Target Sequences: | NM_018222 NP_060692.2 Q9NVD7 |
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