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Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Gene Name: | presenilin associated, rhomboid-like |
Synonyms: | PARL, PSARL, PSARL1, RHBDS1, PRO2207, PSENIP2, Rhomboid 7 homolog 1 |
Target Sequences: | NM_018622 NP_061092.3 Q9H300 |
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