PARK2 / Parkin 2

parkin RBR E3 ubiquitin protein ligase

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30 (PubMed:24896179). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

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Products

Proteins (11)

Type

Over-Expression Lysate (5)

Recombinant (6)

Target

PARK2 / Parkin 2 (11)

Publications

No (11)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His-S (1)

His-SUMO (1)

Myc-DDK (Flag) (5)

Species

Human (9)

Source

293T Cells (3)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human PARK2 / Parkin 2 Protein (Recombinant His) - LS-G2736

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human PARK2 / Parkin 2 Protein (Recombinant GST) (Full Length) - LS-G29623

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PARK2 / Parkin 2 Protein (Recombinant GST, N-terminus) (aa288-387) - LS-G59505

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PARK2 / Parkin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88567

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

20 µg/$150

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Human PARK2 / Parkin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88570

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

20 µg/$215

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Human PARK2 / Parkin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88571

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.5 kDa

Price:

20 µg/$150

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Human PARK2 / Parkin 2 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (aa1-465) - LS-G55967

Source:

Baculovirus

Tag:

10His, N-terminus + Myc, C-terminus

Price:

100 µg/$810; 20 µg/$387; 1 mg/$1,678

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PARK2 / Parkin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114236

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

100 µg/$710

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PARK2 / Parkin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114237

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.5 kDa

Price:

100 µg/$494

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Human PARK2 / Parkin 2 Protein (Recombinant His-S) (aa229-465) - LS-G26087

Source:

E. coli

Tag:

His-S

Molecular Weight:

30.4 kDa

Price:

10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029

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Human PARK2 / Parkin 2 Protein (Recombinant His-SUMO) (Full Length) - LS-G21035

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

67.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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