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Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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PAR / Poly ADP-Ribose
Poly (ADP-ribose) is synthesized by poly(ADP-ribose) polymerases (PARP), which catalyzes the formation of the polymer PADPR, with chain lengths ranging from 2 to 300 residues. PARP is found in the cell’s nucleus. The main role is to detect and signal single-strand DNA breaks (SSB) to the enzymatic machinery involved in the SSB repair. PARP activation is an immediate cellular response to metabolic, chemical, or radiation-induced DNA SSB damage. Once PARP detects a SSB, it binds to the DNA, and, after a structural change, begins the synthesis of a poly (ADP-ribose) chain (PAR) as a signal for the other DNA-repairing enzymes such as DNA ligase III (LigIII), DNA polymerase beta (polß), and scaffolding proteins such as X-ray cross-complementing gene 1 (XRCC1). After repairing, the PAR chains are degraded via Poly(ADP-ribose) glycohydrolase (PARG).
PAR / Poly ADP-Ribose Target Details
| Target Name: | PAR / Poly ADP-Ribose |
Publications (1)
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