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PAPD5
PAP associated domain containing 5
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.
| Gene Name: | PAP associated domain containing 5 |
| Synonyms: | PAPD5, Terminal uridylyltransferase 3, TUTase 3, TRF4-2 |
| Target Sequences: | NM_001040284 |
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