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PANK1 / PANK is a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636).
Gene Name: | pantothenate kinase 1 |
Synonyms: | PANK1, HPanK1, HPanK, Pantothenate kinase 1, Pantothenic acid kinase 1, PANK, PANK1b, PANK1a, Pantothenate kinase |
Target Sequences: | Q8TE04 Q8TE04 |
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