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Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Gene Name: | peptidylglycine alpha-amidating monooxygenase |
Synonyms: | PAM, PAL, Peptidylglycine 2-hydroxylase, Peptidylamidoglycolate lyase, PHM |
Target Sequences: | NM_000919 NP_000910.2 P19021 |
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