PAK2

p21 protein (Cdc42/Rac)-activated kinase 2

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.

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Products

Antibodies (68)

ELISA Kits (4)

Proteins (2)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Primary (68)

Recombinant (2)

Target

PAK2 (74)

Reactivity

Human (71)

Mouse (52)

Rat (42)

Guinea pig (1)

Monkey (2)

Rabbit (1)

Application

IHC (31)

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WB (63)

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ICC (1)

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IP (4)

Peptide-ELISA (10)

Host

rabbit (64)

mouse (4)

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IgG (47)

IgG1 (2)

IgG1,k (1)

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monoclonal mc (5)

polyclonal pc (63)

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Format

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Epitope

aa177-419 (8)

aa192-222 (7)

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No (74)

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Adherent Cell Cultures (4)

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GST, N-terminus (1)

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E. coli (1)

Wheat Germ Extract (1)

Select

IHC-plus™ PAK2 Antibody LS-B537

(4.0) Rating

Antibody:

PAK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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PAK2 Antibody LS-C814064

Antibody:

PAK2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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IHC-plus™ PAK2 Antibody LS-B1384

(4.0) Rating

Antibody:

PAK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

PAK2 Antibody (clone 3B5) LS-C108852

Antibody:

PAK2 Mouse anti-Human Monoclonal (3B5) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$474

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PAK2 Antibody (N-Terminus) LS-C74036

Antibody:

PAK2 Rabbit anti-Human Monoclonal (N-Terminus) Antibody

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$469

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PAK2 Antibody LS-C667444

Antibody:

PAK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

PAK2 Antibody (aa1-212) LS-C377543

Antibody:

PAK2 Rabbit anti-Human Polyclonal (aa1-212) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

PAK2 Antibody LS-C349065

Antibody:

PAK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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PAK2 Antibody LS-C768843

Antibody:

PAK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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PAK2 Antibody LS-C404203

Antibody:

PAK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

PAK2 Antibody (phospho-Ser20) LS-C199408

Antibody:

PAK2 Rabbit anti-Human Polyclonal (pSer20) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

PAK2 Antibody (80-160 aa) LS-C381023

Antibody:

PAK2 Rabbit anti-Human Polyclonal (80-160 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PAK2 Antibody (aa192-222) LS-C328133

Antibody:

PAK2 Rabbit anti-Human Polyclonal (aa192-222) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

PAK2 Antibody (aa192-222, Biotin) LS-C280520

Antibody:

PAK2 Rabbit anti-Human Polyclonal (aa192-222) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PAK2 Antibody (aa192-222, FITC) LS-C280521

Antibody:

PAK2 Rabbit anti-Human Polyclonal (aa192-222) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PAK2 Antibody (aa192-222, APC) LS-C280519

Antibody:

PAK2 Rabbit anti-Human Polyclonal (aa192-222) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

PAK2 Antibody (aa192-222, PE) LS-C280524

Antibody:

PAK2 Rabbit anti-Human Polyclonal (aa192-222) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE

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PAK2 Antibody (1-80 aa) LS-C381296

Antibody:

PAK2 Rabbit anti-Human Polyclonal (1-80 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PAK2 Antibody (aa177-419) LS-C315005

Antibody:

PAK2 Rabbit anti-Human Polyclonal (aa177-419) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

Select

PAK2 Antibody (1-80 aa) LS-C385353

Antibody:

PAK2 Rabbit anti-Human Polyclonal (1-80 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PAK2 Antibody (phospho-Ser20) LS-C822041

Antibody:

PAK2 Rabbit anti-Human Polyclonal (pSer20) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PAK2 Antibody (p20) LS-C822042

Antibody:

PAK2 Rabbit anti-Human Polyclonal (p20) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PAK2 Antibody (aa15-64) LS-C200460

Antibody:

PAK2 Rabbit anti-Human Polyclonal (aa15-64) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

PAK2 Antibody (aa192-222) LS-C99499

Antibody:

PAK2 Rabbit anti-Human Polyclonal (aa192-222) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PAK2 Antibody (Internal) LS-C413140

Antibody:

PAK2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$321

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