PAEL Receptor / GPR37

G protein-coupled receptor 37 (endothelin receptor type B-like)

GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death.

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Products

Proteins (2)

Type

Recombinant (2)

Target

PAEL Receptor / GPR37 (2)

Publications

No (2)

Tag

GST (1)

His (1)

Species

Human (2)

Source

Human Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human PAEL Receptor / GPR37 Protein (Recombinant GST) (Full Length) - LS-G28700

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

93.5 kDa

Price:

2 µg/$439

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Human PAEL Receptor / GPR37 Protein (Recombinant His) (Met1-Met265) - LS-G98591

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

26.6 kDa

Price:

100 µg/$843

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