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PACSIN2

protein kinase C and casein kinase substrate in neurons 2

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.

Gene Name: protein kinase C and casein kinase substrate in neurons 2
Synonyms: PACSIN2, SDPII, Syndapin II
Target Sequences: NM_007229 NP_009160.2 Q9UNF0

Publications (1)

1
The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. de Kreuk BJ, Nethe M, Fernandez-Borja M, Anthony EC, Hensbergen PJ, Deelder AM, Plomann M, Hordijk PL. Journal of cell science. 2011 124:2375-88. [PubMed:21693584] Related Antibodies: LS-C101183.

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Products
Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
PACSIN2 (9)
No (9)
6His, C-terminus (2)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (5)
Human (7)
293T Cells (2)
HEK 293 Cells (3)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (1)
Low endotoxin level (2)
PACSIN2 Protein - 12.5% SDS-PAGE of human PACSIN2 stained with Coomassie Blue
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Wheat Germ Extract
GST
82.1 kDa
10 µg/$479; 25 µg/$670
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
56.7kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
Select
293T Cells
Myc-DDK (Flag)
55.6 kDa
20 µg/$150
PACSIN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
51.8 kDa
20 µg/$150
PACSIN2 Protein - Purified recombinant protein PACSIN2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
55.6 kDa
20 µg/$1,107
PACSIN2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PACSIN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
51.8 kDa
100 µg/$494
PACSIN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
55.6 kDa
100 µg/$494
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
56.7 kDa
10 µg/$317; 50 µg/$524
Viewing 1-9 of 9 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).