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PACAP is a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants.
Gene Name: | adenylate cyclase activating polypeptide 1 (pituitary) |
Family/Subfamily: | Ligand , not assigned-Ligand |
Synonyms: | ADCYAP1, PACAP, Pituitary adenylate cyclase receptor 1 |
Target Sequences: | NM_001117 NP_001108.2 P18509 |
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