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p66 / SHC
SHC (Src homology 2 domain containing) transforming protein 1
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
| Gene Name: | SHC (Src homology 2 domain containing) transforming protein 1 |
| Synonyms: | SHC1, p46 shc, p52 shc, SH2 domain protein C1, p66, SHCA, SHC, SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A |
| Target Sequences: | NM_003029 NP_003020.2 P29353 |
Publications (2)
1
p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy. Xu X, Zhu X, Ma M, Han Y, Hu C, Yuan S, Yang Y, Xiao L, Liu F, Kanwar YS, Sun L. Scientific reports. 2016 6:29302. (WB; Human)
[Full Text Article]
[PubMed:27377870]
[PMC:PMC4932503]
Related Antibodies: LS-C10119.
2
The redox protein p66(shc) mediates cochlear vascular dysfunction and transient noise-induced hearing loss. A R Fetoni, S L M Eramo, F Paciello, R Rolesi, D Samengo, G Paludetti, D Troiani, G Pani. Scientific reports. 2016 May;6:25450. [Full Text Article]
[PubMed:27157635]
[PMC:PMC4860599]
Related Antibodies: LS-C10119.
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(7)
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Human
(7)
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293T Cells
(3)
E. coli
(2)
HEK 293 Cells
(5)
Purification
Purified
(1)
p66 / SHC Mouse anti-Human Monoclonal (3F4) Antibody
Human
ELISA, IF, IHC, IHC-P, PLA, WB
Unconjugated
50 µg/$375
p66 / SHC Mouse anti-Human Monoclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$578; 100 µg/$925
p66 / SHC Rabbit anti-Human Monoclonal (SH2 Domain) (EP332Y) Antibody
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$375
p66 / SHC Mouse anti-Human Monoclonal (pSer36) (6E10) Antibody
Mouse, Dog, Bovine, Rat, Pig, Horse, Human, Monkey
ELISA, WB
Unconjugated
50 µg/$578; 100 µg/$919
p66 / SHC Mouse anti-Human Monoclonal (OTI3A1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI3A1) Antibody
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
p66 / SHC Rabbit anti-Human Polyclonal (aa371-420) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
p66 / SHC Rabbit anti-Human Polyclonal (aa371-420) (HRP) Antibody
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon, Orangutan
WB
HRP Conjugated
100 µl/$469
p66 / SHC Rabbit anti-Human Polyclonal (aa424-440) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$470
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
p66 / SHC Rabbit anti-Human Polyclonal (aa536-564) Antibody
Mouse, Sheep, Rat, Pig, Horse, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$470
p66 / SHC Rabbit anti-Human Polyclonal (pTyr427) Antibody
Human
IHC, WB
Unconjugated
100 µg/$570
p66 / SHC Mouse anti-Human Monoclonal (OTI1H8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI1H8) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
p66 / SHC Rabbit anti-Human Polyclonal (pTyr349) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$282; 200 µl/$350
p66 / SHC Rabbit anti-Human Polyclonal (pTyr427) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$282; 200 µl/$350
p66 / SHC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IP, Peptide-ELISA, WB
Unconjugated
100 µl/$282; 200 µl/$350
p66 / SHC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
p66 / SHC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
p66 / SHC Rabbit anti-Human Polyclonal (p349) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$357
p66 / SHC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$575
p66 / SHC Mouse anti-Human Monoclonal (OTI1D3) Antibody
Flo, IF, WB
Unconjugated
100 µl/$434
p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI1D3) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
p66 / SHC Mouse anti-Human Monoclonal (OTI3H1) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
p66 / SHC Mouse anti-Human Monoclonal (Carrier-free) (OTI3H1) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
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