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P5CR2 / PYCR2
pyrroline-5-carboxylate reductase family, member 2
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP+. Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH.
| Gene Name: | pyrroline-5-carboxylate reductase family, member 2 |
| Synonyms: | PYCR2, p5CR 2, p5C reductase 2, p5CR2 |
| Target Sequences: | NM_013328 NP_037460.2 Q96C36 |
Publications (1)
1
Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination. Nakayama T, Al-Maawali A, El-Quessny M, Rajab A, Khalil S, Stoler JM, Tan WH, Nasir R, Schmitz-Abe K, Hill RS, Partlow JN, Al-Saffar M, Servattalab S, LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G, Barkovich AJ, Markianos K, Poduri A, Mochida GH. American journal of human genetics. 2015 96:709-19. (WB; Human)
[Full Text Article]
[PubMed:25865492]
[PMC:PMC4570282]
Related Antibodies: LS-C115748.
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Proteins
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P5CR2 / PYCR2
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(4)
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Wheat Germ Extract
GST
60 kDa
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
33.5 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
33.5 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
33.5 kDa
20 µg/$150
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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