P40PHOX / NCF4

neutrophil cytosolic factor 4, 40kDa

P40PHOX / NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

P40PHOX / NCF4 (10)

Publications

No (9)

Yes (1)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-T7 (2)

Myc-DDK (Flag) (5)

Species

Human (7)

Mouse (1)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human P40PHOX / NCF4 Protein (Recombinant His) - LS-G1986

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human P40PHOX / NCF4 Protein (Recombinant GST) (Full Length) - LS-G29448

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

65.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human P40PHOX / NCF4 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G59349

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human P40PHOX / NCF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82047

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.9 kDa

Price:

20 µg/$150

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Human P40PHOX / NCF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82048

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.8 kDa

Price:

20 µg/$150

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P40PHOX / NCF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101144

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.8 kDa

Price:

100 µg/$494

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Human P40PHOX / NCF4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68380

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.9 kDa

Price:

20 µg/$1,107

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P40PHOX / NCF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123071

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.9 kDa

Price:

100 µg/$494

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Human P40PHOX / NCF4 Protein (Recombinant His-T7) (aa132-339) - LS-G12004

(4.0) Rating

(1) Publication(s)

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.0 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Mouse P40PHOX / NCF4 Protein (Recombinant His-T7) (aa111-339) - LS-G12008

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.0 kDa

Price:

10 µg/$287; 50 µg/$477; 100 µg/$762; 200 µg/$952; 1 mg/$2,083; 500 µg/$1,613; 5 mg/$3,333; 2 mg/$2,272

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