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P40PHOX / NCF4
neutrophil cytosolic factor 4, 40kDa
P40PHOX / NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
| Gene Name: | neutrophil cytosolic factor 4, 40kDa |
| Synonyms: | NCF4, SH3PXD4, NCF, Neutrophil cytosol factor 4, p40-phox, p40PHOX, NCF-4 |
| Target Sequences: | NM_013416 NP_038202.2 Q15080 |
Publications (1)
1
DPI Selectively Inhibits Intracellular NADPH Oxidase Activity in Human Neutrophils. Alicia Buck, Felix P Sanchez Klose, Vignesh Venkatakrishnan, Arsham Khamzeh, Claes Dahlgren, Karin Christenson, Johan Bylund. The Breast : official journal of the European Society of Mastology. 2019 Oct;3:488-497. [Full Text Article]
[PubMed:31628159]
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P40PHOX / NCF4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
P40PHOX / NCF4 Goat anti-Human Polyclonal (aa228-238) Antibody
Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
P40PHOX / NCF4 Rabbit anti-Human Polyclonal (aa260-289) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
P40PHOX / NCF4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
P40PHOX / NCF4 Mouse anti-Human Monoclonal (OTI4B5) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
P40PHOX / NCF4 Mouse anti-Human Monoclonal (Carrier-free) (OTI4B5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
P40PHOX / NCF4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
P40PHOX / NCF4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
P40PHOX / NCF4 Mouse anti-Human Monoclonal (OTI12H10) Antibody
Human
IHC
Unconjugated
100 µl/$434
P40PHOX / NCF4 Mouse anti-Human Monoclonal (Carrier-free) (OTI12H10) Antibody
Human
IHC
Unconjugated, Carrier-free
100 µg/$511
P40PHOX / NCF4 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
P40PHOX / NCF4 Rabbit anti-Human Polyclonal (90-170 aa) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
P40PHOX / NCF4 Rabbit anti-Human Polyclonal (pThr154) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
P40PHOX / NCF4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
100 µg/$357
P40PHOX / NCF4 Rabbit anti-Human Polyclonal (pThr154) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
100 µg/$357
P40PHOX / NCF4 Rabbit anti-Human Polyclonal (aa120-169) Antibody
Mouse, Human
IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
P40PHOX / NCF4 Rabbit anti-Human Polyclonal (Arg149) Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
50 µl/$321; 100 µl/$403
P40PHOX / NCF4 Mouse anti-Human Monoclonal (3C10) Antibody
Human
ELISA
Unconjugated
100 µg/$423
P40PHOX / NCF4 Rabbit anti-Mouse Polyclonal (aa111-339) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
P40PHOX / NCF4 Mouse anti-Human Monoclonal (Carrier-free) (OTI3E3) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
P40PHOX / NCF4 Mouse anti-Human Monoclonal (Carrier-free) (OTI2D4) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
P40PHOX / NCF4 Mouse anti-Human Monoclonal (Carrier-free) (OTI3E8) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
P40PHOX / NCF4 Mouse anti-Human Monoclonal (Carrier-free) (OTI6H9) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
P40PHOX / NCF4 Mouse anti-Human Monoclonal (Carrier-free) (OTI1A7) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
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