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P2RY6 / P2Y6

pyrimidinergic receptor P2Y, G-protein coupled, 6

P2RY6 / P2Y6 belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Gene Name: pyrimidinergic receptor P2Y, G-protein coupled, 6
Family/Subfamily: GPCR , Purinergic
Synonyms: P2RY6, G-coupled nucleotide receptor, p2 purinoceptor, p2y3 receptor, p2Y purinoceptor 6, Purinergic receptor p2y6, p2RY6, p2y3 and chick, p2Y6 receptor, p2Y6, Purinoceptor p2y6
Target Sequences: NM_004154 NP_004145.1 Q15077

Publications (1)

1
Altered purinergic receptor-Ca²? signaling associated with hypoxia-induced epithelial-mesenchymal transition in breast cancer cells. Azimi I, Beilby H, Davis FM, Marcial DL, Kenny PA, Thompson EW, Roberts-Thomson SJ, Monteith GR. Molecular oncology. 2016 January;10:166-78. (Human) [Full Text Article] [PubMed:26433470] [PMC:PMC5528926]

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Proteins (10)
Over-Expression Lysate (8)
Recombinant (2)
P2RY6 / P2Y6 (10)
No (10)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (8)
Human (6)
293T Cells (4)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (1)
P2RY6 / P2Y6 Protein - 12.5% SDS-PAGE of human P2RY6 stained with Coomassie Blue
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Wheat Germ Extract
GST
62.8 kDa
2 µg/$439
P2RY6 / P2Y6 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
P2RY6 / P2Y6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
36.2 kDa
100 µg/$494
P2RY6 / P2Y6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
36.2 kDa
100 µg/$494
P2RY6 / P2Y6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
36.2 kDa
100 µg/$494
P2RY6 / P2Y6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
36.2 kDa
20 µg/$150
P2RY6 / P2Y6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
36.2 kDa
20 µg/$150
P2RY6 / P2Y6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
36.2 kDa
20 µg/$150
P2RY6 / P2Y6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
36.2 kDa
20 µg/$150
P2RY6 / P2Y6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
36.2 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).