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P2RY14 / GPR105 belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.
Gene Name: | purinergic receptor P2Y, G-protein coupled, 14 |
Family/Subfamily: | GPCR , Sugar sensing |
Synonyms: | P2RY14, G-protein coupled receptor 105, p2Y purinoceptor 14, p2Y(14) receptor, p2Y14 receptor, UDP-glucose receptor, p2Y14, VTR 15-20 receptor, G protein-coupled receptor 105, GPR105, KIAA0001, p2RY14 |
Target Sequences: | NM_014879 NP_055694.3 Q15391 |
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