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P2RY12 / P2Y12

purinergic receptor P2Y, G-protein coupled, 12

P2RY12 / P2Y12 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene.

Gene Name: purinergic receptor P2Y, G-protein coupled, 12
Family/Subfamily: GPCR , Purinergic
Synonyms: P2RY12, ADP-glucose receptor, ADPG-R, p2Y(12)R, p2Y(ADP), p2T(AC), p2Y12, Platelet ADP receptor, SP1999, p2RY12, p2Y purinoceptor 12, Purinergic receptor P2RY12, BDPLT8, Gi-coupled ADP receptor HORK3, HORK3, p2Y(AC), p2Y(cyc), p2Y12 platelet ADP receptor
Target Sequences: NM_022788 NP_073625.1 Q9H244

Publications (1)

1
Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake. Santra Brenna, Hermann C Altmeppen, Behnam Mohammadi, Björn Rissiek, Florence Schlink, Peter Ludewig, Christoph Krisp, Hartmut Schlüter, Antonio Virgilio Failla, Carola Schneider, Markus Glatzel, Berta Puig, Tim Magnus. Journal of Extracellular Vesicles. 2020 August;9:1809065. [Full Text Article] [PubMed:32944194] [PMC:PMC7480459]

☰ Filters
Antibodies (7)
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P2RY12 / P2Y12 (18)
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monoclonal mc (1)
polyclonal pc (6)
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HEK 293 Cells (3)
P2RY12 / P2Y12 Antibody - Anti-P2RY12 / P2Y12 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer
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P2RY12 / P2Y12 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IHC, IHC-P
Unconjugated
50 µg/$440
P2RY12 / P2Y12 Antibody - Anti-P2RY12 / P2Y12 antibody IHC of human bone marrow, megakaryocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
P2RY12 / P2Y12 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Rabbit, Dog, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
P2RY12 / P2Y12 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
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P2RY12 / P2Y12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
P2RY12 / P2Y12 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
P2RY12 / P2Y12 Antibody - 1:200 staining rat brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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P2RY12 / P2Y12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
P2RY12 / P2Y12 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
P2RY12 / P2Y12 Antibody - Western blot analysis using P2RY12 mAb against human P2RY12 (AA: extra mix) recombinant protein. (Expected MW is 9.4 kDa)
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P2RY12 / P2Y12 Mouse anti-Human Monoclonal (1C2A9) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
P2RY12 / P2Y12 Protein - Purified recombinant protein P2RY12 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
39.3 kDa
20 µg/$1,107
P2RY12 / P2Y12 Antibody - Western blot analysis of extracts of various cell lines, using P2RY12 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 180s.
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P2RY12 / P2Y12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
P2RY12 / P2Y12 Antibody - Anti-Human P2Y12 Receptor staining (10 µg/ml) of a human bone marrow formalin-fixed, paraffin-embedded tissue section; seen at 20x magnification. Staining of bone marrow cells and interstitium is observed.
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P2RY12 / P2Y12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
100 µg/$491
P2RY12 / P2Y12 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
P2RY12 / P2Y12 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
P2RY12 / P2Y12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.3 kDa
20 µg/$150
P2RY12 / P2Y12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.3 kDa
20 µg/$150
P2RY12 / P2Y12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.3 kDa
100 µg/$494
P2RY12 / P2Y12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.3 kDa
100 µg/$494
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E. coli
10His, N-terminus
100 µg/$1,801; 20 µg/$1,247
Viewing 1-18 of 18 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).