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P2RX7 / P2X7

purinergic receptor P2X, ligand-gated ion channel, 7

P2RX7 / P2X7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.

Gene Name: purinergic receptor P2X, ligand-gated ion channel, 7
Family/Subfamily: Ion Channel , P2X receptor
Synonyms: P2RX7, ATP receptor, p2X purinoceptor 7, p2X receptor 7, p2X7 purinoceptor, p2Z receptor, Purinergic receptor, p2RX7, p2X7, p2X7 receptor
Target Sequences: NM_002562 NP_002553.3 Q99572

Publications (2)

1
Signaling through purinergic receptors for ATP induces human cutaneous innate and adaptive Th17 responses: implications in the pathogenesis of psoriasis. Killeen ME, Ferris L, Kupetsky EA, Falo L Jr, Mathers AR. Journal of immunology (Baltimore, Md. : 1950). 2013 190:4324-36. (IF; Human) [Full Text Article] [PubMed:23479230] [PMC:PMC3622186] Related Antibodies: LS-A9585.
2
Anti-apoptotic Effects of Bone Marrow on Human Islets: A Preliminary Report. Luo LG, Luo JZ. Journal of stem cell research & therapy. 2015 5: (IHC; Human) [Full Text Article] [PubMed:26229735] [PMC:PMC4517837] Related Antibodies: LS-A9585.

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Products
Antibodies (42)
Primary (42)
P2RX7 / P2X7 (42)
Human (35)
Mouse (22)
Rat (13)
Bovine (6)
Chimpanzee (3)
Dog (3)
Gibbon (6)
Guinea pig (3)
Hamster (1)
Horse (6)
Monkey (1)
Pig (8)
IHC (12)
IHC-P (6)
WB (35)
Flo (6)
ELISA (8)
ICC (1)
IF (5)
Peptide-ELISA (2)
rabbit (35)
mouse (1)
goat (1)
rat (5)
Product Group
IHCPlus (3)
IgG (15)
IgG2b (6)
monoclonal mc (6)
polyclonal pc (36)
7G1D6 (1)
Hano43 (1)
HANO43 (1)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (21)
aa47-334 (8)
aa563-592 (7)
C-Terminus (5)
aa71-120 (4)
Internal (1)
Ser390 (1)
aa1-20 (1)
aa13-26 (1)
aa226-452 (1)
aa40-105 (1)
No (41)
Yes (1)
P2RX7 / P2X7 Antibody - Anti-P2RX7 / P2X7 antibody IHC of human pancreas, nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
P2RX7 / P2X7 Antibody - Anti-P2RX7 / P2X7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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P2RX7 / P2X7 Goat anti-Human Polyclonal (aa13-26) Antibody
Hamster, Pig, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
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P2RX7 / P2X7 Rat anti-Mouse Monoclonal (Hano43) Antibody
Mouse
Flo, IF
Unconjugated
0.1 mg/$385; 0.25 mg/$471
P2RX7 / P2X7 Antibody - Western blot of P2RX7 / P2X7 antibody.
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa47-334) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
P2RX7 / P2X7 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
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P2RX7 / P2X7 Rabbit anti-Mouse Polyclonal (aa40-105) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
P2RX7 / P2X7 Antibody - P2RX7 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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P2RX7 / P2X7 Mouse anti-Human Monoclonal (aa226-452) (7G1D6) Antibody
Human
ELISA, Flo, IHC-P, WB
Unconjugated
100 µl/$459
P2RX7 / P2X7 Antibody - P2RX7 / P2X7 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa71-120) Antibody
Human
WB
Unconjugated
100 µl/$424
P2RX7 / P2X7 Antibody - P2RX7 / P2X7 antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
P2RX7 / P2X7 Antibody - Western blot analysis of extracts of various cell lines, using P2RX7 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
P2RX7 / P2X7 Antibody - Sample (50 ug of tissue extract) A: normal mouse brain tissue 7.5% SDS PAGE P2RX7 / P2X7 antibody diluted at 1:1000
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P2RX7 / P2X7 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat
WB
Unconjugated
100 µl/$450
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
P2RX7 / P2X7 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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P2RX7 / P2X7 Rat anti-Mouse Monoclonal (HANO43) Antibody
Mouse
Flo
Unconjugated
100 µg/$562; 250 µg/$755
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P2RX7 / P2X7 Rat anti-Mouse Monoclonal (HRP) Antibody
Mouse
Flo, IF
HRP Conjugated
100 µl/$830
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P2RX7 / P2X7 Rat anti-Mouse Monoclonal (Biotin) Antibody
Mouse
Flo, IF
Biotin Conjugated
100 µl/$830
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P2RX7 / P2X7 Rat anti-Mouse Monoclonal (PE) Antibody
Mouse
Flo, IF
PE Conjugated
100 µl/$830
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$357
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (Ser390) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$357
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).