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P2RX7 / P2X7
purinergic receptor P2X, ligand-gated ion channel, 7
P2RX7 / P2X7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
| Gene Name: | purinergic receptor P2X, ligand-gated ion channel, 7 |
| Family/Subfamily: | Ion Channel , P2X receptor |
| Synonyms: | P2RX7, ATP receptor, p2X purinoceptor 7, p2X receptor 7, p2X7 purinoceptor, p2Z receptor, Purinergic receptor, p2RX7, p2X7, p2X7 receptor |
| Target Sequences: | NM_002562 NP_002553.3 Q99572 |
Publications (2)
1
Signaling through purinergic receptors for ATP induces human cutaneous innate and adaptive Th17 responses: implications in the pathogenesis of psoriasis. Killeen ME, Ferris L, Kupetsky EA, Falo L Jr, Mathers AR. Journal of immunology (Baltimore, Md. : 1950). 2013 190:4324-36. (IF; Human)
[Full Text Article]
[PubMed:23479230]
[PMC:PMC3622186]
Related Antibodies: LS-A9585.
2
Anti-apoptotic Effects of Bone Marrow on Human Islets: A Preliminary Report. Luo LG, Luo JZ. Journal of stem cell research & therapy. 2015 5: (IHC; Human)
[Full Text Article]
[PubMed:26229735]
[PMC:PMC4517837]
Related Antibodies: LS-A9585.
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P2RX7 / P2X7 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
P2RX7 / P2X7 Goat anti-Human Polyclonal (aa13-26) Antibody
Hamster, Pig, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
P2RX7 / P2X7 Rat anti-Mouse Monoclonal (Hano43) Antibody
Mouse
Flo, IF
Unconjugated
0.1 mg/$385; 0.25 mg/$471
P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa47-334) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
E. coli
His-TRX
36.8 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
P2RX7 / P2X7 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
P2RX7 / P2X7 Rabbit anti-Mouse Polyclonal (aa40-105) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
293T Cells
Myc-DDK (Flag)
68.4 kDa
20 µg/$215
P2RX7 / P2X7 Mouse anti-Human Monoclonal (aa226-452) (7G1D6) Antibody
Human
ELISA, Flo, IHC-P, WB
Unconjugated
100 µl/$459
P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa71-120) Antibody
Human
WB
Unconjugated
100 µl/$424
P2RX7 / P2X7 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
P2RX7 / P2X7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
P2RX7 / P2X7 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat
WB
Unconjugated
100 µl/$450
HEK 293 Cells
Myc-DDK (Flag)
68.4 kDa
100 µg/$710
P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
P2RX7 / P2X7 Rabbit anti-Human Polyclonal (aa563-592) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
P2RX7 / P2X7 Rabbit anti-Human Polyclonal Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
P2RX7 / P2X7 Rat anti-Mouse Monoclonal (HRP) Antibody
Mouse
Flo, IF
HRP Conjugated
100 µl/$830
P2RX7 / P2X7 Rat anti-Mouse Monoclonal (Biotin) Antibody
Mouse
Flo, IF
Biotin Conjugated
100 µl/$830
P2RX7 / P2X7 Rat anti-Mouse Monoclonal (PE) Antibody
Mouse
Flo, IF
PE Conjugated
100 µl/$830
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