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OSTM1 is a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.
Gene Name: | osteopetrosis associated transmembrane protein 1 |
Synonyms: | OSTM1, Grey-lethal osteopetrosis, GL, HSPC019, OPTB5, GIPN |
Target Sequences: | NM_014028 NP_054747.2 Q86WC4 |
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