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OSM / Oncostatin M

oncostatin M

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.

Gene Name: oncostatin M
Synonyms: OSM, Oncostatin-M, Oncostatin M
Target Sequences: NM_020530 NP_065391.1 P13725

Publications (2)

1
Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies. Seungwon An, Ilangovan Raju, Bayasgalan Surenkhuu, Ji-Eun Kwon, Shilpa Gulati, Muge Karaman, Anubhav Pradeep, Satyabrata Sinha, Christine Mun, Sandeep Jain. The ocular surface. 2019 July;17:589-614. [Full Text Article] [PubMed:30965123] [PMC:PMC6721977] Related Antibodies: LS-C104796.
2
Hyperbaric oxygen suppresses stemness-associated properties and Nanog and oncostatin M expression, but upregulates ß-catenin in orthotopic glioma models. Kun Song, Junrui Chen, Jianbo Ding, Hao Xu, Hongzhi Xu, Zhiyong Qin. The Journal of international medical research. 2019 Mar;48:300060519872898. [Full Text Article] [PubMed:31813325] [PMC:PMC7607208]

☰ Filters
Products
Proteins (36)
Over-Expression Lysate (2)
Recombinant (34)
OSM / Oncostatin M (36)
Bind (1)
ELISA (1)
Func (1)
SDS-PAGE (4)
Animal-free (1)
No (36)
10His, N-terminus (1)
6His, N-terminus (3)
6His-SUMO, N-terminus (1)
GST (2)
His (5)
His,C-terminus (2)
His,N-terminus (1)
His-GST (1)
Myc-DDK (Flag) (3)
Human (25)
Mouse (7)
Rat (3)
293T Cells (1)
E. coli (23)
HEK 293 Cells (8)
Human (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Yeast (1)
Purified (14)
Low endotoxin level (16)
Biologically active (17)
Animal-free (1)
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
20.5 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
Select
HEK 293 Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
10-40 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
25.7 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
23.6 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$282; 10 µg/$370
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
24.4 kDa
2 µg/$268; 10 µg/$349
OSM / Oncostatin M Protein
Select
E. coli
None
Biologically active
22.0 kDa
10 µg/$388; 100 µg/$1,661; 500 µg/$3,629
OSM / Oncostatin M Protein
Select
E. coli
None
Biologically active
25.8 kDa
10 µg/$388; 100 µg/$1,661; 500 µg/$3,629
OSM / Oncostatin M Protein
Select
E. coli
None
Biologically active
23.7 kDa
10 µg/$388; 100 µg/$1,661; 500 µg/$3,629
OSM / Oncostatin M Protein - Eukaryotic Oncostatin M By SDS-PAGE
Select
Human
None
23.5kDa
50 µg/$642; 10 µg/$313; 200 µg/$1,214; 100 µg/$1,020; 1 mg/$2,450; 500 µg/$1,952; 5 mg/$4,481; 2 mg/$2,642
OSM / Oncostatin M Protein - Purified recombinant protein OSM was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
25.7 kDa
20 µg/$1,107
Select
E. coli
GST
49.4 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Select
HEK 293 Cells
His
23.5 kDa
10 µg/$339; 50 µg/$642; 100 µg/$962
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
23.8 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
OSM / Oncostatin M Protein - 12.5% SDS-PAGE of human OSM stained with Coomassie Blue
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Wheat Germ Extract
GST
54.9 kDa
2 µg/$439
OSM / Oncostatin M Protein - Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.5-2.5 ng/ml.
Select
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human OSM consists of 207 amino acids and has a predicted molecular mass of 23.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhOSM is approximately 32-35 kDa due to glycosylation.
100 µg/$480; 1 mg/$2,333
OSM / Oncostatin M Protein - Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.2-1 ng/mL.
Select
HEK 293 Cells
None
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human OSM consists 196 amino acids and predicts a molecular mass of 22.2 kDa.
20 µg/$403; 100 µg/$761; 1 mg/$3,016
OSM / Oncostatin M Protein - Measured in a cell proliferation assay using NIH3T3 cells. The ED50 for this effect is typically 2-12 ng/mL.
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse OSM comprises 193 amino acids and has a calculated molecular mass of 22 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 35-40 kDa in SDS-PAGE under reducing conditions.
100 µg/$480; 1 mg/$2,333
OSM / Oncostatin M Protein - Measured in a cell proliferation assay using NIH3T3 cells. The ED50 for this effect is typically 8-32 ng/mL.
Select
E. coli
None
SDS-PAGE
Biologically active
The recombinant mouse OSM consists of 184 amino acids and predicts a molecular mass of 20.7 kDa. It migrates as an approximately 23 kDa band in SDS-PAGE under reducing conditions.
20 µg/$333; 100 µg/$519; 1 mg/$2,675
OSM / Oncostatin M Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
25.7 kDa
20 µg/$150
OSM / Oncostatin M Protein
Select
E. coli
None
Less than 0.1 EU/µg protein (determined by LAL method).
28.6 kDa
20 µg/$677
OSM / Oncostatin M Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
25.7 kDa
100 µg/$494
Select
HEK 293 Cells
None
Biologically active
22.2 kDa or 32-34 kDa
10 µg/$349; 2 µg/$268
OSM / Oncostatin M Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
10His, N-terminus
24.2 kDa
100 µg/$1,374; 20 µg/$543; 1 mg/$5,176
OSM / Oncostatin M Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
22.6 kDa
100 µg/$570; 20 µg/$395; 1 mg/$1,973
Viewing 1-25 of 36 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).