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Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | osteoclast associated, immunoglobulin-like receptor |
Synonyms: | OSCAR, HOSCAR, Osteoclast-associated receptor, PIgR-3, PIGR3, Poly-Ig receptor 3 |
Target Sequences: | NM_206818 NP_996554.2 Q8IYS5 |
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