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Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
Gene Name: | oxysterol binding protein |
Synonyms: | OSBP, OSBP1, Oxysterol binding protein, Oxysterol-binding protein 1 |
Target Sequences: | NM_002556 NP_002547.1 P22059 |
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