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Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Gene Name: | origin recognition complex, subunit 4 |
Synonyms: | ORC4, ORC4P, ORC4L, HsORC4 |
Target Sequences: | NM_002552 NP_002543.2 O43929 |
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