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OPRL1 / ORL1
opiate receptor-like 1
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
| Gene Name: | opiate receptor-like 1 |
| Family/Subfamily: | GPCR , Opioid |
| Synonyms: | OPRL1, Kappa-type 3 opioid receptor, KOR-3, Kor3, N/OFQ receptor, Nop receptor, Opioid receptor-like protein, Opiate receptor-like 1, Orphanin FQ receptor, Kappa3-related opioid receptor, Xor1, Nociceptin receptor, NOCIR, OOR, Opioid receptor-like 1, ORL1, Ror-c |
| Target Sequences: | NM_000913 NP_000904.1 P41146 |
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