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G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
Gene Name: | opioid receptor, delta 1 |
Family/Subfamily: | GPCR , Opioid |
Synonyms: | OPRD1, D-OR-1, Delta-type opioid receptor, Delta opioid receptor, Delta opiate receptor, Delta opioid receptor 1, Delta-1 opioid receptor, Opioid delta receptor, DOR-1, Opioid receptor, delta 1, OPRD |
Target Sequences: | NM_000911 NP_000902.3 P41143 |
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