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OPRD1 / Delta Opioid Receptor

opioid receptor, delta 1

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Gene Name: opioid receptor, delta 1
Family/Subfamily: GPCR , Opioid
Synonyms: OPRD1, D-OR-1, Delta-type opioid receptor, Delta opioid receptor, Delta opiate receptor, Delta opioid receptor 1, Delta-1 opioid receptor, Opioid delta receptor, DOR-1, Opioid receptor, delta 1, OPRD
Target Sequences: NM_000911 NP_000902.3 P41143

Publications (2)

1
Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons. Wang HB, Zhao B, Zhong YQ, Li KC, Li ZY, Wang Q, Lu YJ, Zhang ZN, He SQ, Zheng HC, Wu SX, Hökfelt TG, Bao L, Zhang X. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:13117-22. (ICC; Rat) [Full Text Article] [PubMed:20615975] [PMC:PMC2919913]
2
Opioid receptor delta as a global modulator of skin differentiation and barrier function repair. H Chajra, B Amstutz, K Schweikert, D Auriol, G Redziniak, F Lefèvre. International journal of cosmetic science. 2015 August;37:386-94. [Full Text Article] [PubMed:25660727] Related Antibodies: LS-A222.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).