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In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2).
Gene Name: | oleoyl-ACP hydrolase |
Synonyms: | OLAH, AURA1, SAST, Thioesterase II, Oleoyl-ACP hydrolase, THEDC1 |
Target Sequences: | NM_018324 NP_060794.1 Q9NV23 |
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