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OGG1

8-oxoguanine DNA glycosylase

OGG1 is the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.

Gene Name:	8-oxoguanine DNA glycosylase
Synonyms:	OGG1, 8-oxoguanine DNA glycosylase, AP lyase, HMMH, N-glycosylase/DNA lyase, HOGG1, OGH1, OGG1 type 1f, MMH, MUTM
Target Sequences:	NM_016819 NP_058212.1 O15527

Publications (47)

Zinc(II) inhibits the release of thyroid and glucocorticoid receptors from chromatin of cultured GC cells. Ramirez IJ, Halwer M, Shapiro LE, Surks MI. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et mtabolisme. 1991 23:155-61. (IHC; Mouse, Rat) [PubMed:1908429]

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. Sakumi K, Furuichi M, Tsuzuki T, Kakuma T, Kawabata S, Maki H, Sekiguchi M. The Journal of biological chemistry. 1993 268:23524-30. [PubMed:8226881]

Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III. Hilbert TP, Chaung W, Boorstein RJ, Cunningham RP, Teebor GW. The Journal of biological chemistry. 1997 272:6733-40. [PubMed:9045706]

A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. Lu R, Nash HM, Verdine GL. Current biology : CB. 1997 7:397-407. [PubMed:9197244]

Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. Radicella JP, Dherin C, Desmaze C, Fox MS, Boiteux S. Proceedings of the National Academy of Sciences of the United States of America. 1997 94:8010-5. [PubMed:9223305] [PMC:PMC21547]

Anti-ROS-DNA monoclonal antibody as molecular probe for oxidative DNA damage. Ashok BT, Ahmad J, Qadri A, Ali R. Biochemistry and molecular biology international. 1997 43:1219-29. [PubMed:9442918]

Binding of circulating antibodies to reactive oxygen species modified-DNA and detecting DNA damage by a monoclonal antibody probe. Ashok BT, Ali R. Mechanisms of ageing and development. 1998 103:69-80. [PubMed:9681880]

Human MMH (OGG1) type 1a protein is a major enzyme for repair of 8-hydroxyguanine lesions in human cells. Monden Y, Arai T, Asano M, Ohtsuka E, Aburatani H, Nishimura S. Biochemical and biophysical research communications. 1999 258:605-10. [PubMed:10329432]

Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles. Tsurudome Y, Hirano T, Yamato H, Tanaka I, Sagai M, Hirano H, Nagata N, Itoh H, Kasai H. Carcinogenesis. 1999 20:1573-6. [PubMed:10426809]

Up-regulation of base excision repair activity for 8-hydroxy-2'-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion. Lin LH, Cao S, Yu L, Cui J, Hamilton WJ, Liu PK. Journal of neurochemistry. 2000 74:1098-105. [PubMed:10693941] [PMC:PMC2726712]

hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population. Wikman H, Risch A, Klimek F, Schmezer P, Spiegelhalder B, Dienemann H, Kayser K, Schulz V, Drings P, Bartsch H. International journal of cancer. Journal international du cancer. 2000 88:932-7. [PubMed:11093817]

Frequent allelic imbalance and loss of protein expression of the DNA repair gene hOGG1 in head and neck squamous cell carcinoma. Fan CY, Liu KL, Huang HY, Barnes EL, Swalsky PA, Bakker A, Woods J, Finkelstein SD. Laboratory investigation; a journal of technical methods and pathology. 2001 81:1429-38. [PubMed:11598155]

Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells. Hodges NJ, Chipman JK. Carcinogenesis. 2002 23:55-60. [PubMed:11756223]

Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines. Mambo E, Nyaga SG, Bohr VA, Evans MK. Cancer research. 2002 62:1349-55. [PubMed:11888904]

Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes. Tyrberg B, Anachkov KA, Dib SA, Wang-Rodriguez J, Yoon KH, Levine F. BMC endocrine disorders. 2002 2:2. [PubMed:12003641] [PMC:PMC111186]

Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death. Dobson AW, Grishko V, LeDoux SP, Kelley MR, Wilson GL, Gillespie MN. American journal of physiology. Lung cellular and molecular physiology. 2002 283:L205-10. [PubMed:12060578]

Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria. Rachek LI, Grishko VI, Musiyenko SI, Kelley MR, LeDoux SP, Wilson GL. The Journal of biological chemistry. 2002 277:44932-7. [PubMed:12244119]

Cadmium exposure down-regulates 8-oxoguanine DNA glycosylase expression in rat lung and alveolar epithelial cells. Potts RJ, Watkin RD, Hart BA. Toxicology. 2003 184:189-202. [PubMed:12499121]

Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein. Tuo J, Chen C, Zeng X, Christiansen M, Bohr VA. DNA repair. 2002 1:913-27. [PubMed:12531019]

DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA. Stuart JA, Hashiguchi K, Wilson DM, Copeland WC, Souza-Pinto NC, Bohr VA. Nucleic acids research. 2004 32:2181-92. [PubMed:15107486] [PMC:PMC407819]

The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity. Hashiguchi K, Stuart JA, de Souza-Pinto NC, Bohr VA. Nucleic acids research. 2004 32:5596-608. [PubMed:15494448] [PMC:PMC524278]

Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells. Ruchko M, Gorodnya O, LeDoux SP, Alexeyev MF, Al-Mehdi AB, Gillespie MN. American journal of physiology. Lung cellular and molecular physiology. 2005 288:L530-5. [PubMed:15563690]

In vivo inosine protects alveolar epithelial type 2 cells against hyperoxia-induced DNA damage through MAP kinase signaling. Buckley S, Barsky L, Weinberg K, Warburton D. American journal of physiology. Lung cellular and molecular physiology. 2005 288:L569-75. [PubMed:15579626]

Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes. Protective role of targeting 8-oxoguanine glycosylase to mitochondria. Druzhyna NM, Musiyenko SI, Wilson GL, LeDoux SP. The Journal of biological chemistry. 2005 280:21673-9. [PubMed:15811855]

Induction of OGG1 gene expression by HIV-1 Tat. Imai K, Nakata K, Kawai K, Hamano T, Mei N, Kasai H, Okamoto T. The Journal of biological chemistry. 2005 280:26701-13. [PubMed:15929986]

The effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity. Chatterjee A, Mambo E, Osada M, Upadhyay S, Sidransky D. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 20:112-4. [PubMed:16293709]

beta(2)-Adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy. Xydas S, Kherani AR, Chang JS, Klotz S, Hay I, Mutrie CJ, Moss GW, Gu A, Schulman AR, Gao D, Hu D, Wu EX, Wei C, Oz MC, Wang J. The Journal of pharmacology and experimental therapeutics. 2006 317:553-61. [PubMed:16421285]

Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria. Rachek LI, Thornley NP, Grishko VI, LeDoux SP, Wilson GL. Diabetes. 2006 55:1022-8. [PubMed:16567524]

The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells. Chen D, Yu Z, Zhu Z, Lopez CD. Cancer research. 2006 66:3485-94. [PubMed:16585172]

Human 8-oxoguanine-DNA glycosylase 1 protein and gene are expressed more abundantly in the superficial than basal layer of human epidermis. Javeri A, Huang XX, Bernerd F, Mason RS, Halliday GM. DNA repair. 2008 7:1542-50. [PubMed:18585103]

Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase. Simone S, Gorin Y, Velagapudi C, Abboud HE, Habib SL. Diabetes. 2008 57:2626-36. [PubMed:18599524] [PMC:PMC2551671]

Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA. Salas TR, Petruseva I, Lavrik O, Saintom C. Nucleic acids research. 2009 37:38-46. [PubMed:19010961] [PMC:PMC2615627]

The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells. de Souza-Pinto NC, Maynard S, Hashiguchi K, Hu J, Muftuoglu M, Bohr VA. Molecular and cellular biology. 2009 29:4441-54. [PubMed:19506022] [PMC:PMC2725742]

Base excision repair of reactive oxygen species-initiated 7,8-dihydro-8-oxo-2'-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs. Preston TJ, Henderson JT, McCallum GP, Wells PG. Molecular cancer therapeutics. 2009 8:2015-26. [PubMed:19567822] [PMC:PMC2711226]

Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. Song Y, Leonard SW, Traber MG, Ho E. The Journal of nutrition. 2009 139:1626-31. [PubMed:19625698] [PMC:PMC3151020]

Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells. Yan T, Seo Y, Kinsella TJ. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:6912-20. [PubMed:19861440] [PMC:PMC2783277]

Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice. Wu M, Huang H, Zhang W, Kannan S, Weaver A, McKibben M, Herington D, Zeng H, Gao H. Infection and immunity. 2011 79:75-87. [PubMed:20956573] [PMC:PMC3019904]

Dynamics of the primate ovarian surface epithelium during the ovulatory menstrual cycle. Wright JW, Jurevic L, Stouffer RL. Human reproduction (Oxford, England). 2011 26:1408-21. [PubMed:21421660] [PMC:PMC3096557]

Role of the Nrf2-ARE pathway in acrylamide neurotoxicity. Zhang L, Gavin T, Barber DS, LoPachin RM. Toxicology letters. 2011 205:7-Jan. (WB; Rat) [PubMed:21540084] [PMC:PMC3149808]

Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype. Karihtala P, Kauppila S, Puistola U, Jukkola-Vuorinen A. British journal of cancer. 2012 106:344-7. [PubMed:22108520] [PMC:PMC3261678]

Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility. Wang HT, Hu Y, Tong D, Huang J, Gu L, Wu XR, Chung FL, Li GM, Tang MS. The Journal of biological chemistry. 2012 287:12379-86. [PubMed:22275365] [PMC:PMC3320987]

Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1. Siggens L, Figg N, Bennett M, Foo R. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 26:2117-24. (WB; Mouse, Rat) [PubMed:22302830]

Human 8-oxoguanine-DNA glycosylase-1 is downregulated in human basal cell carcinoma. Huang XX, Scolyer RA, Abubakar A, Halliday GM. Molecular genetics and metabolism. 2012 106:127-30. (IHC; Human) [PubMed:22436579]

Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders. Zhang Y, Wang M, Li H, Zhang H, Shi Y, Wei F, Liu D, Liu K, Chen D. Brain research. 2012 1458:11-Jan. (ICC, IHC-Fr; Human) [PubMed:22554480]

Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes. Kadekaro AL, Chen J, Yang J, Chen S, Jameson J, Swope VB, Cheng T, Kadakia M, Abdel-Malek Z. Molecular cancer research : MCR. 2012 10:778-86. (WB; Human) [PubMed:22622028]

Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons. Hill JW, Poddar R, Thompson JF, Rosenberg GA, Yang Y. Neuroscience. 2012 220:277-90. (WB; Rat) [PubMed:22710064]

Evaluation of immunohistochemical markers to detect the genotoxic mode of action of fine and ultrafine dusts in rat lungs. Rittinghausen S, Bellmann B, Creutzenberg O, Ernst H, Kolling A, Mangelsdorf I, Kellner R, Beneke S, Ziemann C. Toxicology. 2013 303:177-86. (IHC; Rat) [PubMed:23178243]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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