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ODC1 / Ornithine Decarboxylase is the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
Gene Name: | ornithine decarboxylase 1 |
Synonyms: | ODC1, Ornithine decarboxylase, ODC, Ornithine decarboxylase 1 |
Target Sequences: | NM_002539 NP_002530.1 P11926 |
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