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OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
| Gene Name: | 2'-5'-oligoadenylate synthetase 1, 40/46kDa |
| Synonyms: | OAS1, 2,5-oligo A synthetase 1, 2-5A synthetase 1, 2-5A synthase 1, 2-5-oligoadenylate synthase 1, E18/E16, OIASI, OIAS, p46/p42 OAS, IFI-4 |
| Target Sequences: | NM_016816 NP_058132.2 P00973 |
Publications (5)
1
Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:1828-33.
[PubMed:16446426]
[PMC:PMC1413670]
Related Antibodies: LS-C100473.
2
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L. Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ. Journal of virology. 2007 81:5561-72.
[PubMed:17344297]
[PMC:PMC1900262]
Related Antibodies: LS-C100473.
3
Overexpression of OAS1 Is Correlated With Poor Prognosis in Pancreatic Cancer. Lingling Lu, Huaxiang Wang, Jian Fang, Jiaolong Zheng, Bang Liu, Lei Xia, Dongliang Li. Frontiers in oncology. 2022 July;12:944194. [Full Text Article]
[PubMed:35898870]
[PMC:PMC9309611]
Related Antibodies: LS-B6622.
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OAS1
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(53)
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(53)
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(51)
Yes
(2)
OAS1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
OAS1 Rabbit anti-Human Polyclonal (aa324-373) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
OAS1 Rabbit anti-Human Polyclonal (aa324-373) (HRP) Antibody
Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
OAS1 Rabbit anti-Human Polyclonal (aa324-373) (Biotin) Antibody
Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
OAS1 Rabbit anti-Human Polyclonal (aa324-373) (FITC) Antibody
Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
OAS1 Rabbit anti-Human Polyclonal (aa302-330) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
OAS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
OAS1 Rabbit anti-Human Polyclonal (aa1-215) Antibody
Human
IHC, WB
Unconjugated
100 µl/$332
OAS1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386
OAS1 Rabbit anti-Human Polyclonal (aa288-337) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
OAS1 Rabbit anti-Human Polyclonal (aa288-337) (HRP) Antibody
Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
OAS1 Rabbit anti-Human Polyclonal (aa288-337) (Biotin) Antibody
Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
OAS1 Rabbit anti-Human Polyclonal (aa288-337) (FITC) Antibody
Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
OAS1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
OAS1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
OAS1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
OAS1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
OAS1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
OAS1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
OAS1 Rabbit anti-Human Polyclonal (aa302-330) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
OAS1 Rabbit anti-Human Polyclonal (aa302-330) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
OAS1 Rabbit anti-Human Polyclonal (aa302-330) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
OAS1 Rabbit anti-Human Polyclonal (aa302-330) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
OAS1 Rabbit anti-Human Polyclonal (aa302-330) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
OAS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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