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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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O3FAR1 / GPR120
free fatty acid receptor 4
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. Mizuta K, Zhang Y, Mizuta F, Hoshijima H, Shiga T, Masaki E, Emala CW Sr. American journal of physiology. Lung cellular and molecular physiology. 2015 309:L970-82. (WB; Human)[Full Text Article]
[PubMed:26342087]
[PMC:PMC4628981]
2
Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index. Little TJ, Isaacs NJ, Young RL, Ott R, Nguyen NQ, Rayner CK, Horowitz M, Feinle-Bisset C. American journal of physiology. Gastrointestinal and liver physiology. 2014 307:G958-67. (IHC; Human)[Full Text Article]
[PubMed:25258406]
Related Antibodies: LS-A2003.
3
Effects of ovarian hormones on GPR120 mRNA expression in mouse pituitary gonadotrophs. Moriyama R, Ueda K, Deura C. Endocrine Journal. 2017 November;64:1055-1061. [Full Text Article]
[PubMed:28824022]
4
Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats. Yu Abekura, Isao Ono, Akitsugu Kawashima, Katsumi Takizawa, Hirokazu Koseki, Haruka Miyata, Kampei Shimizu, Mieko Oka, Mika Kushamae, Susumu Miyamoto, Hiroharu Kataoka, Akira Ishii, Tomohiro Aoki. Journal of neuroinflammation. 2020 Apr;17:129. [Full Text Article]
[PubMed:32331514]
[PMC:PMC7181479]
Related Antibodies: LS-A2003.
5
G protein-coupled receptors in human fat taste perception. Galindo MM, Voigt N, Stein J, van Lengerich J, Raguse JD, Hofmann T, Meyerhof W, Behrens M. Gastroenterology. 2014 Feb;37:123-39. [Full Text Article]
[PubMed:21868624]
Related Antibodies: LS-A2003.
6
CD36- and GPR120-mediated Ca2+ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice. Ozdener MH, Subramaniam S, Sundaresan S, Sery O, Hashimoto T, Asakawa Y, Besnard P, Abumrad NA, Khan NA. Gastroenterology. Apr;146:995-1005. [Full Text Article]
[PubMed:24412488]
[PMC:PMC3979457]
Related Antibodies: LS-A2003.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).