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NUMA1 / NUMA
nuclear mitotic apparatus protein 1
Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.
| Gene Name: | nuclear mitotic apparatus protein 1 |
| Synonyms: | NUMA1, Structural nuclear protein, NuMA protein, SP-H antigen, NUMA |
| Target Sequences: | NM_006185 NP_006176.2 Q14980 |
Publications (3)
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