NUDR / DEAF1

DEAF1 transcription factor

Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm.

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Products

Proteins (3)

Type

Recombinant (3)

Target

NUDR / DEAF1 (3)

Publications

No (3)

Tag

GST (1)

GST, N-terminus (2)

Species

Human (3)

Source

Wheat Germ Extract (3)

Purification

Purified (1)

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Human NUDR / DEAF1 Protein (Recombinant GST) (Full Length) - LS-G32197

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

85.7 kDa

Price:

2 µg/$439

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Human NUDR / DEAF1 Protein (Recombinant GST, N-terminus) (aa466-564) - LS-G61543

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NUDR / DEAF1 Protein (Recombinant GST, N-terminus) (aa133-222) - LS-G61545

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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