NUAK1 / ARK5

NUAK family, SNF1-like kinase, 1

Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

NUAK1 / ARK5 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human NUAK1 / ARK5 Protein (Recombinant His-T7) (aa421-658) - LS-G26157

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.9 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human NUAK1 / ARK5 Protein (Recombinant GST, N-terminus) (aa371-470) - LS-G61275

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse NUAK1 / ARK5 Protein (Recombinant His-GST) (aa404-651) - LS-G26158

Source:

E. coli

Tag:

His-GST

Molecular Weight:

57.2 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human NUAK1 / ARK5 Protein (Recombinant GST) (Full Length) - LS-G31838

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

100.7 kDa

Price:

2 µg/$439

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NUAK1 / ARK5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101266

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.1 kDa

Price:

100 µg/$710

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Human NUAK1 / ARK5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79927

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.1 kDa

Price:

20 µg/$215

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